Department: Barts Cancer Institute
Salary: £34,733 - £45,479 (Grade 5)
Location: Charterhouse Square
Date posted: 22-Nov-2021
Closing date: 10-Dec-2021
Barts Cancer Institute, Centre for Cancer Genomics and Computational Biology
Post title: Postdoctoral Research Assistant Post ref: QMUL26122
About the Role
We are looking for a self-motivated and independent-thinking wet-lab scientist to explore new methods to decipher specific genome instability mechanisms from cancer genomes. You will be working with a genomics bioinformatician to analyse the data and devise relevant genomic signatures. We are therefore looking for someone with a keen interest and background knowledge in the fundamentals of accurate human cell division processes, and the ability to interact with non-computational and computational colleagues.
You will have a PhD in a relevant subject, and be skilled in the majority of wet-lab techniques required to complete the project. You will have experience with replication stress in cancer, specifically how to induce and manipulate replication stress in human cells. You will have a good understanding of the role of genome instability in tumour heterogeneity and evolution, and an understanding of cell division processes.
About the School/Department/Institute/Project
The Barts Cancer Institute (BCI) hosts some of the most eminent cancer research teams in London. As part of the Barts and The London School of Medicine and Dentistry (Queen Mary University of London), research at the BCI focuses on how to reduce the burden of disease and improve patient survival through early detection and diagnosis and the discovery and development of more effective and innovative therapies.
The McClelland laboratory has recently developed a genetic replication stress signature by analyzing the immediate effects of replication stress on the genome at the single-cell level (Mazzagatti et al, BioRXiv, 2020). This project builds on these findings and will integrate further experimental modelling of additional replication stresses, with bioinformatic approaches to analyse related replication stress signatures from tumour genomes.
About Queen Mary
At Queen Mary University of London, we believe that a diversity of ideas helps us achieve the previously unthinkable.
Throughout our history, we’ve fostered social justice and improved lives through academic excellence. And we continue to live and breathe this spirit today, not because it’s simply ‘the right thing to do’ but for what it helps us achieve and the intellectual brilliance it delivers.
We continue to embrace diversity of thought and opinion in everything we do, in the belief that when views collide, disciplines interact, and perspectives intersect, truly original thought takes form.
We offer competitive salaries, access to a generous pension scheme, 30 days’ leave per annum (pro-rata for part-time/fixed-term), a season ticket loan scheme and access to a comprehensive range of personal and professional development opportunities.
The post is based at the Charterhouse Square campus in London. It is full time (35 hours per week), fixed term appointment for 12 months, with an expected start date of Wednesday 12th January 2021. The starting salary will be Grade 4/5, £34,733 - £45,479 per annum, inclusive of London Allowance.
Queen Mary’s commitment to our diverse and inclusive community is embedded in our appointments processes. We are open to considering applications from candidates wishing to work flexibly.
Informal enquiries should be addressed to Nick Summerfield at firstname.lastname@example.org.
The closing date for applications is Friday 10th December 2021.
The School of Medicine and Athena SWAN Charter for Women in Science.
Valuing Diversity & Committed to Equality