Department: Blizard Institute
Salary: £34,220 - £40,194 per annum (Grade 4)
Date posted: 19-Nov-2020
Closing date: 19-Dec-2020
About the Role
Tissue or cell type specific expression of genes is regulated by multiple cis-regulatory elements called enhancers. Histone acetylations, in particular acetylation of histone H3 at lysine 27 (H3K27ac) is widely used as marker to identify active enhancers in a tissue or cell type. Dr Madapura’s work shows that a large number of active enhancers lack detectable H3K27ac, but are enriched for acetylations at histone H4 tail lysine 16 (H4K16ac) and the globular domain of histone H3 at lysine 122 (H3K122ac). Dr Madapura’s group is investigating the specific role of histone acetyltransferases in tissue-specific gene expression, with a focus on the human neuronal differentiation system and their alterations in neurodevelopmental disorders. This project aims to investigate the role of specific histone acetylations on cell type specific enhancer function. The post-holder will generate and analyse epigenomic datasets like ChIP-seq/CutandTag-seq, RNA-seq, promoter capture Hi-C and Massively Parallel Reporter Assays upon depletion of specific histone acetyltransferase complexes.
We are looking for applicants with knowledge and technical experience in genomics and molecular biology. Applicants require bioinformatics analysis skills, and will ideally also have expertise in gene regulation. Molecular biology experience is desirable but not essential.
The Blizard Institute was established in 2003 and is the largest of seven Institutes within Barts and the London School of Medicine and Dentistry, Queen Mary University of London. The Institute comprises approximately 400 staff based in five academic centres and one Public Engagement Centre, and supports a combined total of c750 postgraduate research and taught students. The Institute delivers excellence in all aspects of research, teaching and clinical service.
About Queen Mary
At Queen Mary University of London, we believe that a diversity of ideas helps us achieve the previously unthinkable.
Throughout our history, we’ve fostered social justice and improved lives through academic excellence. And we continue to live and breathe this spirit today, not because it’s simply ‘the right thing to do’ but for what it helps us achieve and the intellectual brilliance it delivers.
We continue to embrace diversity of thought and opinion in everything we do, in the belief that when views collide, disciplines interact, and perspectives intersect, truly original thought takes form.
We offer competitive salaries, access to a generous pension scheme, 30 days’ leave per annum (pro-rata for part-time/fixed-term), a season ticket loan scheme and access to a comprehensive range of personal and professional development opportunities. In addition, we offer a range of work life balance and family friendly, inclusive employment policies, flexible working arrangements, and campus facilities including an on-site nursery at the Mile End campus.
This Medical Research Council UK funded post is based at the Whitechapel Campus in London. It is a full time, fixed term appointment for 1 year, available to start as soon as possible. The starting salary will be Grade 4, in the range of £34,220 - £40,194 per annum, inclusive of London Allowance.
Queen Mary’s commitment to our diverse and inclusive community is embedded in our appointments processes. Reasonable adjustments will be made at each stage of the recruitment process for any candidate with a disability. We are open to considering applications from candidates wishing to work flexibly.
Informal enquiries should be addressed to Dr Pradeepa Madapura at firstname.lastname@example.org or on +44 (0) 020 7882 2594.
To apply for the role, please click the ‘apply’ button below.
The closing date for applications is 19 December 2020.
Interviews are expected to be held shortly thereafter.
The School of Medicine holds a Silver Athena SWAN Award. We are committed to the equality of opportunities and to advancing women’s careers. We have policies to support staff returning from long-term absence, for flexible arrangements for staff with parental responsibilities and for childcare support. As part of the School’s commitment to the Athena SWAN principles we strongly encourage applications from women.
Valuing Diversity & Committed to Equality