Department: School of Engineering & Materials Science
Salary: £33,615 - £35,459 (Grade 4)
Date posted: 23-Oct-2018
Closing date: 25-Nov-2018
Queen Mary is one of London and the UK’s leading research-focused universities. With over 20,000 students, it is amongst the largest of the colleges of the University of London. Queen Mary’s 4,000 staff teach and research across a wide range of subjects in Science and Engineering, the Humanities, Social Sciences and Laws, and Medicine and Dentistry.
This post is within the School of Engineering and Materials Science, a large School with approximately 70 academic staff and around 45 postdoctoral research staff. There are around 1000 undergraduate and taught postgraduate students and 220 PhD students. Circa 40 administrative and technical staff support the staff and students. The staff and student body are international in make-up. The School is partway through a refurbishment project that is upgrading research and teaching space. The School holds a departmental-level Bronze Athena SWAN award and is committed to equality of opportunity.
About the role
Applications are invited for a full-time Postdoctoral Research Assistant to investigate mechanical sensing in cardiomyocytes. The post will be based within the School of Engineering and Material Sciences, Queen Mary University of London.
The composition and the stiffness of the cardiac extracellular matrix (ECM) change during development or in heart disease. Cardiomyocytes (CMs) and their progenitors sense these changes, which decides over the cell fate and can trigger CM (progenitor) proliferation, differentiation, de-differentiation or death. Our preliminary data suggested a cardiomyocyte specific rigidity sensing mechanism, but molecular details are still lacking. Also differences in the mechanical sensing and signalling between cardiomyocytes of different maturity are still elusive. This BBSRC-funded project uses state of the art nanotechnology, biophysical and imaging approaches to identify the key mechanosensitive elements in cardiomyocytes - depending on substrate stiffness, extracellular matrix composition and cardiomyocyte maturity or health.
Applicants should have a PhD in a relevant subject (e.g. mechanobiology, biophysics, cardiovascular or stem cell biology). They should have prior research experience and contributions using mechanobiology or biophysical techniques, advanced imaging approaches, and computational analysis, as well as extensive experience with cell culture (ideally using induced pluripotent stem cells). Solid knowledge of cardiovascular and especially cardiomyocyte biology are desirable.
For further details of the role and selection criteria please refer to the job specification attached.
The post is full time (35 hours per week), on a fixed term of 36 months, with an expected start date of Jan 2nd 2018. Starting salary will be in the range of £33,615 - £35,459 per annum, inclusive of London Allowance. Benefits include 30 days annual leave, pension scheme and interest-free season ticket loan.
Candidates must be able to demonstrate their eligibility to work in the UK in accordance with the Immigration, Asylum and Nationality Act 2006. Where required this may include entry clearance or continued leave to remain under the Points Based Immigration Scheme.
Informal enquiries should be addressed to Thomas Iskratsch on firstname.lastname@example.org
Details about the school can be found at www.sems.qmul.ac.uk
To apply for the role, please click the ‘apply’ button below.
The closing date for applications is 25 November 2018. Interviews are expected to be held shortly thereafter.
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