Department: Barts Cancer Institute
Salary: Starting salary will be in the range £33,615-£39,483 per annum inclusive of London Allowance. (Grade 4)
Location: Charterhouse Square
Date posted: 12-Feb-2019
Closing date: 12-Mar-2019
The newly established Haematopoietic Stem Cell and Leukaemia Laboratory welcomes applications for a highly motivated postdoctoral scientist with expertise in RNA biology or a related subject. This position is funded by a recently awarded 5-year CRUK Programme Grant. The project will focus on the impact of the epitranscriptome on stem cell biology and leukaemic transformation. Our central aim is to discover how RNA modifications control normal stem cell functions and leukaemic transformation and exploit these mechanisms to expand haematopoietic stem cells (HSC) and eradicate cancer stem cells in acute myeloid leukaemia (AML). This programme will join a novel and emerging field of epitranscriptome and cancer biology thus offering opportunity for multidisciplinary training (in stem cell/cancer biology, molecular biology and bioinformatics), new discovery and excellent career development.
The research will be based in the world-renowned Centre for Haemato-Oncology, Barts Cancer Institute, within the Barts and The London School of Medicine and Dentistry, Queen Mary University of London.
Essential requirements for this post include a PhD in a relevant biological subject related to RNA biology. Significant research laboratory experience in molecular biology, RNA biology/epitranscriptome, omics approaches (e.g. RNA-seq, CLIP-seq, ChIP-seq) and protein biochemistry are essential. A publication track record in the RNA field would be an advantage.
This project will be supervised by Prof. Kamil K Kranc (Barts Cancer Institute) and Prof. Donal O’Carroll (University of Edinburgh). Our research combines expertise in stem cell and leukaemia biology and RNA molecular biology. Selected publications from the Kranc and O’Carroll laboratories: Guitart et al., J. Exp. Med., 2017; Vukovic et al., J. Exp. Med., 2015; Ivanova et al., Mol Cell, 2017; Morgan et al., Nature, 2017
The post is a fixed term position for 36 months in the first instance (with a possibility of extension for extra 2 years). Starting salary will be in the range £33,615-£39,483 per annum inclusive of London Allowance. Benefits include 30 days annual leave, pension scheme and an interest free season ticket loan.
The Barts Cancer Institute requires applicants to provide all certificates at interview to confirm their qualifications (specified in the Job Description).
Candidates must be able to demonstrate their eligibility to work in the UK in accordance with the Immigration, Asylum and Nationality Act 2006. Where required this may include entry clearance or continued leave to remain under the Points Based Immigration Scheme.
Informal enquiries about this post are strongly encouraged. Arrangements to visit the Institute/Centre, can be arranged upon request. Please contact Professor Kamil Kranc (firstname.lastname@example.org) for further information.
Details about Barts Cancer Institute can be found at www.bci.qmul.ac.uk
The closing date for applications is 12 March 2019. Interviews are expected to be held shortly thereafter.
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