Department: Centre for Tumour Biology, Barts Cancer Institute
Salary: £32,956 (Grade 4)
Date posted: 02-Jan-2018
Closing date: 01-Feb-2018
Barts Cancer Institute
Centre for Tumour Biology
Postdoctoral Research Assistant
Targeting Stromal Activation in Pancreatic Cancer
Applications are sought for a Postdoctoral Research Assistant to undertake research under the supervision of the Principal Investigator, Dr Angus Cameron, to study molecular mechanisms governing pancreatic cancer progression and resistance to therapy. The research, funded by Worldwide Cancer Research, will be based in the Centre for Tumour Biology, Barts Cancer Institute, within the Barts and the London School of Medicine and Dentistry, Queen Mary University of London.
Essential requirements for this post include a PhD, or equivalent, in a relevant biological subject and an undergraduate degree in a biological subject. The successful candidate will have research experience in cell biology, molecular biology and ideally expertise with in vivo models of cancer. The ability to work independently, as well as in a team, and to communicate well are essential skills.
Pancreatic cancer remains a devastating disease with 5-year survival rates below 5%. Part of the reason for this poor outcome is that pancreatic tumours are highly fibrotic and do not respond well to therapy. We are investigating a novel approach to improve chemotherapy and immunotherapy responses by targeting the fibrotic tumour microenvironment. We have identified a signalling pathway which is critical for the activation of pancreatic cancer stromal cells and the goals of the current project are to (i) define the molecular mechanisms underlying pathway function using a combination of proteomics, molecular biology and cell biology, and (ii) identify the therapeutic value of pathway targeting using in vivo pancreatic cancer models, CyTOF mass cytometry and tumour pathology; impact on both chemotherapy and immunotherapy will be addressed.
Targeting the tumour microenvironment is a hot topic in the pancreatic cancer field and a specialist area of focus at Barts Cancer Institute. The project will involve collaboration with tumour biology specialist Professor Kairbaan Hodivala-Dilke and leading pancreatic cancer clinician Professor Hemant Kocher, and will suit a team player with a desire to conduct fundamental molecular research in an area of significant unmet clinical need.
The post is a full time, fixed term position for 3 years. Starting salary will be £32,956 per annum inclusive of London Allowance. Benefits include 30 days annual leave, a defined benefit pension scheme and an interest free season ticket loan.
The Barts Cancer Institute requires that applicants invited for interview will need to provide all certificates to confirm their qualifications (specified in the Job Description).
Candidates must be able to demonstrate their eligibility to work in the UK in accordance with the Immigration, Asylum and Nationality Act 2006. Where required this may include entry clearance or continued leave to remain under the Points Based Immigration Scheme.
Informal enquiries about this post, including arrangements to visit the Institute/Centre, can be made to Angus Cameron tel: 0207 882 6538 or email: firstname.lastname@example.org
Details about Barts Cancer Institute can be found at www.bci.qmul.ac.uk
To apply, please visit the Human Resources website on http://www.hr.qmul.ac.uk/vacancies and search for reference QMUL13662.
The closing date is 01 February 2018 and the interviews are likely to be held shortly after. It is expected that the position will commence on 1st March 2018 or as soon as possible thereafter.
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