Human Resources

Postdoctoral Research Assistant (genetics) - QMUL13517

Department: Centre for Tumour Biology, Barts Cancer Institute
Salary: £32,956 - £36,677 (Grade 4)
Reference: QMUL13517
Date posted: 12-Dec-2017
Closing date: 15-Jan-2018

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Applications are sought for a Postdoctoral Research Assistant to research the evolution of Barrett’s oesopahagus to cancer. The successful applicant will work under the supervision of Dr Stuart McDonald, the Principal Investigator (PI) ( of the Clonal Dynamics in Epithelia laboratory, in order to realise the objectives of a Cancer Research UK funded programme predicting risk of cancer development in patients with Barrett’s oesophagus. This is a multidisciplinary group that includes other wet lab scientists, bioinformaticians and clinicians.

Barrett’s oesophagus is the major precursor lesion of oesophageal adenocarcinoma (OAC) in the UK. OAC has a poor survival rate and Barrett’s is common but conversion to cancer is rare. However ALL Barrett’s patients undergo regular endoscopic surveillance for signs of cancer which is expensive and yet there are no biomarkers to predict cancer risk, therefore surveillance is life-long. We believe that this is because we do not understand the evolution of Barrett’s to cancer. We are seeking a postdoctoral scientist to investigate how Barrett’s evolves, in particular investigating the clonal relationships between different histological features and how these change over time. Experience in genetics (sequencing) and histology is essential. 

We will study a cohort of Barrett’s patients over time that either have or have not progressed to cancer, to determine evolutionary patterns that can predict cancer risk. The post will involve using next generation sequencing techniques. The successful candidate will also be expected to help drive the direction of the project and help develop novel methodology that will allow clinicians to stratify patient surveillance based on cancer risk.

The research will be based in the Centre for Tumour Biology, Barts Cancer Institute, within the Barts and The London School of Medicine and Dentistry, Queen Mary University of London.

Essential requirements for this post include a PhD in genetics or a relevant subject and an interest in cancer biology. Furthermore, an appropriate publication record is essential. A demonstrated ability to communicate well, work within a team and maintain good laboratory records are also essential.

The post is a full time, fixed term position for 2 years (with a further 3 years upon programme renewal). Starting salary will be in the range £32,956 - £36,677 per annum inclusive of London Allowance. Benefits include 30 days annual leave, a defined benefit pension scheme and an interest free season ticket loan.

The Barts Cancer Institute requires applicants to provide all certificates at interview to confirm their qualifications (specified in the job description).

Candidates must be eligible to work in the UK in accordance with the Immigration, Asylum and Nationality Act 2006. Where required this may include entry clearance or continued leave to remain under the Points Based Immigration Scheme.

Informal enquiries about this post, including arrangements to visit the Institute/Centre are encouraged and can be made to Dr Stuart McDonald Tel: 0207 882 3800 or email

Details about Barts Cancer Institute can be found at

To apply, and for full job details, please visit the Human Resources website on and search for reference

The closing date is 15th January 2018 and the interviews are likely to be held in the week commencing 22nd January 2018 or as near to this as is possible. It is expected the position will commence as soon as possible after then.

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